Displaying 1 - 35 of 41

Characterization of Optical Pumping of Ti Beam into a Metastable State

Diego A Peña : Physics Summer 2019

Laser cooling and trapping consists of using light’s momentum to slow down and eventually confine atoms to small regions of space using light and magnetic fields. These techniques have been demonstrated with many elements in the periodic table, yet most transition metals are still to be addressed. A current effort in the Stamper-Kurn group seeks to implement laser cooling on titanium,... Read More

Investigating the Mechanism of NLRP1 Inflammasome Activation by Dengue Virus Protease

Rimjhim Agarwal : MCB-Infectious Diseases Summer 2019

Dengue virus (DENV) is the leading cause of death in dengue-endemic areas. An infection resulting from DENV can manifest as serious human disease, such as Dengue hemorrhagic fever or Dengue shock syndrome. Currently there is no effective vaccine to prevent the infection. My project seeks to understand critical host-virus interactions between DENV and multi-protein innate immune cytosolic... Read More

Investigating Root-Multiplicities of Kac-Moody Algebras

Aidan Backus : Mathematics Summer 2019

Over the summer, we propose to investigate the root multiplicities of (generalized) Kac-Moody Algebras. Our plan is to create an open-source computer package that allows for the computation of root multiplicities of Kac-Moody algebras, building upon the existing tools available to computational mathematicians, for instance, the popular library sage-math. Once we have developed and verified... Read More

Optimization of CRISPR-Cas9 using an Adeno-Associated Virus (AAV) Delivered Self-Inactivation System

Andrew Chen : Molecular & Cellular Biology Summer 2019

CRISPR-Cas9 is a versatile genome-editing technology that is widely used to modify genome sequences linked to genetic abnormalities. Often, the CRISPR-Cas9 system is used to target or repair disease-causing versions of genes, delete fragments of unwanted DNA, and insert therapeutic gene sequences to treat diseases. However, many studies have shown that CRISPR-Cas9 can cause unexpected... Read More

Investigating the Regulation of Atg40 Expression During Meiosis

Tia Cheunkarndee : MCB and Public Health Summer 2019

Autophagy is a process of “self-eating” by which the cell targets specific cargo for degradation. While autophagy was initially believed to primarily be a response to stress or starvation, it is now known that it also plays important roles in cellular homeostasis and organismal development. This process can happen either non-selectively, where cargo is degraded randomly in bulk, or selectively... Read More

Comparative Dual RNA-Seq Transcriptome Profiling of Host-Pathogen Interactions During Chlamydia Trachomatis Infection of Human Primary Endocervical Cells

Siddharth Chittaranjan : MCB (Immunology) and English Summer 2019

Microbes pose a wide spectrum of nonpathogenic and pathogenic challenges for the immune system. The encounters are governed by the interactions between the bacterium’s adaptations and the host’s ability to mount a protective immune response. Chlamydia trachomatis (Ct) is an especially unique pathogen as the infections it causes in the genital tract are typically asymptomatic. While this... Read More

Investigating Root-Multiplicities of Kac-Moody Algebras

Peter Connick : Physics and Math (math undeclared) Summer 2019

Over the summer, we propose to investigate the root multiplicities of (generalized) Kac-Moody Algebras. Our plan is to create an open-source computer package that allows for the computation of root multiplicities of Kac-Moody algebras, building upon the existing tools available to computational mathematicians, for instance, the popular library sage-math. Once we have developed and verified... Read More

Numerical Simulation of the Ejecta Velocity Distribution of Type Ia Supernovae

Keto, De Zhang : Astrophysics and Data Science Summer 2019

Type Ia supernovae (SNe Ia) are generally thought to be the thermonuclear disruption of a carbon-oxygen white-dwarf star, but their formation scenarios and exact progenitor systems are still ambiguous. SNe Ia are used as standardizable candles used for measuring distances in the universe. Famously, SNe Ia are being used to determine the acceleration at which the universe is expanding (i.e.,... Read More

Exploring Mechanisms Behind the Oxygen Dependence of Listeria Monocytogenes Intracellular Replication

Davy Deng : MCB-Genetics, Genomics and Development; Chemical Biology; Psychology Summer 2019

Listeria monocytogenes is a pathogen often found in poorly preserved food , especially dairy products. L. monocytogenes can survive with or without oxygen as well as inside or outside of host cells. During infection, L. monocytogenes must pass through the low-oxygen environment in the intestines before entering the high-oxygen target tissue. It thus stands to reason that both aerobic and... Read More

Schubert Calculus Through Toric Geometry

Junhao Fan : Math Summer 2019

In our research, we will use toric geometry to study the cohomological structure of complex Grassmannians. The cohomology ring of a Grassmannian varieties is described by the Littlewood-Richardson rule. One of the main open questions in Schubert calculus concerns the generalization of the Littlewood-Richardson rule to flag varieties. Such a generalization is highly desirable, because it is a... Read More

Systematics and Paleoecology of Plio–Pleistocene Shrews from South Africa

Kendall Fitzgerald : Integrative Biology Summer 2019

One of the most ambitious expeditions in the history of UC Berkeley has yet to be completed. In 1947, the University of California Africa Expedition, led by researchers from the UC Berkeley Museum of Paleontology, set out for southern Africa to collect fossils from early hominid sites. However, upon their return, many of the micro-mammal fossils were stored away without being properly examined... Read More

Investigating the Role of Alternative mRNA Transcripts in SOD1 During Meiosis

Mounika Gopi : Molecular and Cell Biology (Cell and Developmental Biology emphasis) Summer 2019

... Read More

Experimental Implementation of RF Electron Traps and Trapped-Electron Qubits

Jinen (Timothy) Guo : Physics Summer 2019

Quantum algorithms that take advantage of principles of quantum mechanics are able to solve certain problems (e.g. factorization of a large integer) much more efficiently than classical algorithms. One of the most promising candidates for qubit (the equivalent of a classical bit in quantum computing) implementation is the trapped ion. Although there have been promising results in trapped ion... Read More

SLASER & JDE Analysis for MRI

Arya Haghighi : Biochemistry Summer 2019

The inhibition of glutathione, a buffer which maintains redox balance in neural cells, has recently been implicated as part of the pathology of multiple sclerosis (MS), a chronic and debilitating neurological disease. Magnetic resonance spectroscopy is a non-invasive technique which can quantitatively measure glutathione, amongst other metabolites, in the brain using the semi-localized by... Read More

In Vitro Analysis of Cardiomyocyte Binucleation in H9C2 Cell Line

Shea Khyeam : Molecular and Cell Biology & Nutritional Sciences Summer 2019

Although animals such as zebrafish and newborn mice retain the ability to regenerate the heart post-injury, adult mammalians have largely lost this cardiac regenerative capacity. Consequently, a patient will irreversibly lose as many as a billion cardiomyocytes following a heart attack and suffer from permanently reduced cardiac function. Today, nearly five million Americans live with heart... Read More

Molecular Determinants and Mechanism of Flavivirus NS1-Induced Endothelial Permeability

Jasmine Larrick : Molecular and Cell Biology Summer 2019

A hallmark of severe dengue virus (DENV) infection is vascular leak. DENV non-structural protein 1 (NS1) directly triggers endothelial hyperpermeability and vascular leak via disruption of the endothelial glycocalyx layer (EGL). The EGL is a matrix of glycoproteins and membrane-bound proteoglycans lining the vascular endothelium, playing a protective role in maintaining endothelial barrier... Read More

Thermal Metal-Insulator Transition in Single Layer 1T-TaSe2

Ryan Lee : Physics and Mathematics Summer 2019

... Read More

The Effects of China's Two-Child Policy on Women's Labor Market Outcomes

Zihao Li : Applied Mathematics, Economics, Statistics Summer 2019

In the past few decades, due to the strict implementation of the one-child policy in China, it had been almost impossible to conduct any research related to having a second child. However, China has been gradually relaxing this policy. Since November 2011, parents who are both the only child in their families may have two children. Since December 2013, couples in which only one parent is the... Read More

Coordination of Organelle Inheritance During Polarized Cell Division

Kathryn Li : Molecular and Cell Biology Summer 2019

During cell division, many cellular materials cannot be produced de novo and therefore must be partitioned equally between the two daughter cells. In the budding yeast Saccharomyces cerevisiae, material produced in the mother cell must be actively transported to the growing daughter cell during cell division. Molecular pathways of how individual organelles are transported to the daughter cell... Read More

Development of a Novel Silicon Photomultiplier Telescope Camera to Search for Optical Counterparts to Fast Radio Bursts

Siyang Li : Physics Summer 2019

Fast Radio Bursts (FRB) are high-energy millisecond duration radio signals of unknown astrophysical origins whose localizations are limited by the inherently low resolutions of radio telescopes. Recent theories propose that the origins of FRB may also produce nanosecond duration optical counterparts which, if observed with higher resolution optical telescopes, would allow astronomers to... Read More

Investigating the Role of TREK1 Ion Channels in Social Memory

Vivian Li : Molecular and Cellular Biology (Neurobiology) Summer 2019

The firing properties of a neuron are not only influenced by the electrical and chemical signals it receives, but also by the physical properties of its environment. Their ability to detect stimuli such as pH, temperature, and mechanical pressure allows a neuron to change its excitability in response. Two-pore domain potassium (K2P) ion channels are of particular importance because they are... Read More

Application of the TES as a Radioactive Decay Detector

Mingyu Li : Physics and Applied Math Summer 2019

Neutrino-less double beta decay is a process that is forbidden in the current Standard Model of particle physics since it violates lepton number conservation. If observed, this type of decay can provide insight into fundamental neutrino properties, such as whether neutrinos are Majorana or Dirac fermions (i.e. whether they are their own anti-particles). This decay also provides information on... Read More

Investigating Root-Multiplicities of Kac-Moody Algebras

Joshua Lin : Mathematics and Physics Summer 2019

Over the summer, we propose to investigate the root multiplicities of (generalized) Kac-Moody Algebras. Our plan is to create an open-source computer package that allows for the computation of root multiplicities of Kac-Moody algebras, building upon the existing tools available to computational mathematicians, for instance, the popular library sage-math. Once we have developed and verified... Read More

Schubert Calculus Through Toric Geometry

Yining Liu : Math Summer 2019

In our research, we will use toric geometry to study the cohomological structure of complex Grassmannians. The cohomology ring of a Grassmannian varieties is described by the Littlewood-Richardson rule. One of the main open questions in Schubert calculus concerns the generalization of the Littlewood-Richardson rule to flag varieties. Such a generalization is highly desirable, because it is a... Read More

Investigating the Role of plk-2 in Regulating the Synaptic Checkpoint in Meiosis

Zoe Lung : Molecular and Cell Biology Summer 2019

Meiosis is an essential cell division process that involves the reduction of chromosome number, thus creating haploid cells from diploid cells. Since mistakes in this process can lead to aneuploidy and many genetic defects such as cancer, this division is highly regulated and consists of many regulatory checkpoints. One such checkpoint, referred to as the synaptic checkpoint, is necessary... Read More

A Novel Approach to Fluency Data Analysis to Improve Dementia Diagnosis

Samira Maboudian : Cognitive Science Major, Bioengineering Minor Summer 2019

In 2018, an estimated 50 million people worldwide were living with dementia. However, there is currently no single, universal cognitive assessment to diagnose dementia. Many of the tests and metrics used are either too simple or take too long to administer in a clinical setting. Some common diagnostic screenings are also hindered by questionable validity and low sensitivity. Issues with these... Read More

Impact of Baryons on Intrinsic Galaxy Alignments using Cosmological Simulations

Hunter Martin : Mathematics and Physics Summer 2019

One of the principal probes of cosmology is weak gravitational lensing whereby gravitational effects of mass bend the path of light. This causes small but correlated distortions in the images of distant galaxies which we can measure and then use to study the distribution of matter over cosmological distances and time scales. However, one of the fundamental assumptions of this method is that... Read More

Tempo of Cooling through the Middle Ordovician Using δ18Ophosphate from Conodont Elements

Fran Meyer : Geology Summer 2019

The paleoclimate of the Ordovician period (485 to 444 million years ago) is of particular interest to geologists and paleontologists because of a great biodiversification event followed by a mass extinction associated with a global glaciation. To answer why there was such a drastic change in climate, we must first understand when these trends began. While it is well-established that the... Read More

Sulfur Abundance and Isotopic Composition Across the Terrestrial Cretaceous-Paleogene Boundary

Nicole Mizrahi : Geology Summer 2019

The Cretaceous-Paleogene (K-Pg) mass extinction (~66 million years ago) is hypothesized to have been caused by environmental effects of the Chicxulub asteroid impact and/or Deccan Traps flood volcanism in India. Both potentially caused major climatic change through increased sulfate aerosol production, which would have caused significant global cooling and/or acid rain. Sulfur released by each... Read More

Investigating Root-Multiplicities of Kac-Moody Algebras

Chris Randall : Math Summer 2019

Over the summer, we propose to investigate the root multiplicities of (generalized) Kac-Moody Algebras. Our plan is to create an open-source computer package that allows for the computation of root multiplicities of Kac-Moody algebras, building upon the existing tools available to computational mathematicians, for instance, the popular library sage-math. Once we have developed and verified... Read More

Investigating Allostery in the T4 Bacteriophage Clamp Loader

Peter Ren : Chemical Biology and Computer Science Summer 2019

The AAA+ proteins (ATPases Associated with a variety of cellular Activities) are a highly diverse and ancient protein superfamily present in all organisms and are involved in such processes such as DNA replication, protein degradation, and metal insertion in protein synthesis. AAA+ proteins have some conserved features, including an oligomeric ring structure that exhibits inter-protomer... Read More

Photoassociation and STIRAP on Ultracold LiRb Molecules

Dalila Robledo : Physics Summer 2019

The experiment that I will be working on this summer is currently being set up to prepare lithium-rubidium ultracold molecules. Ultracold molecules are those whose kinetic temperature as a measure of their velocity distribution is close to zero Kelvin, the regime where quantum effects of matter dominate.

An interesting property of this particular molecule is its intrinsically large... Read More

Schubert Calculus Through Toric Geometry

Nikhil Sahoo : Pure Math Summer 2019

In our research, we will use toric geometry to study the cohomological structure of complex Grassmannians. The cohomology ring of a Grassmannian varieties is described by the Littlewood-Richardson rule. One of the main open questions in Schubert calculus concerns the generalization of the Littlewood-Richardson rule to flag varieties. Such a generalization is highly desirable, because it is a... Read More

A Hillslope Stability Analysis by Use of Soil Characterization and Pore Pressure Measurements

Maryn Sanders : Geophysics Summer 2019

The unique site of Antelope Valley River near Williams, California has for a few years been a place of interest and research because of the distinct sedimentary layering and the very regular pattern of hills and hollows. In the winter of 2017, a huge storm came through the site and induced four hundred landslides. Another storm then followed in the winter of 2019 at a much lesser degree of... Read More

Pages