Displaying 1 - 19 of 19

Active Chromatin Marks Modulate the Activity of the Crucial Epigenetic Silencer PRC2

Curtis Beck : MCB, Biochemistry and Structural Biology Summer 2020

In mammals, Polycomb Repressive Complex 2 (PRC2) plays a crucial role in maintaining the gene-expression patterns that enforce cell differentiation during embryonic development. Mutations in the core components of PRC2 or its associated cofactors result in early embryonic lethality. PRC2 represses transcription by mono-, di- and tri-methylating histone H3 at lysine 27... Read More

Characterization of A. thaliana Transcription Activators

Jasmine Cisneros : Chemistry Major, Bioengineering Minor Summer 2020

The field of metabolic engineering has expanded to utilize plants as an expression host in the biotechnology industry and current research. Transcription factors (TFs) are one of the many intriguing components in the plants’ metabolic pathways as they regulate the expression of the enzymes involved. While TFs are integral for control of gene expression, most TFs... Read More

Investigating the Role of the Single-Stranded DNase Activity of CRISPR-Cas12a

Bayan Duwaik : Molecular & Cell Biology -- Immunology Summer 2020

CRISPR-Cas systems are indispensable tools in genome editing because they allow scientists to edit an individual’s DNA to correct harmful mutations that cause disease. CRISPR-Cas systems are derived from bacteria and archaea where they act as an adaptive immune system of these organisms by targeting viral DNA and RNA for degradation and elimination. Recently, studies... Read More

Investigating the Molecular Mechanisms of RME through NK Cell Receptors

Alec Ethell : Molecular and Cell Biology Summer 2020

Mammalian cells typically possess two homologous copies of each gene: one paternal and one maternal. Most developmentally regulated genes express both copies, but monoallelic (single copy) gene expression is a pervasive phenomenon. Some mitotically stable examples of this pattern have been described in autosomal genes and are often referred to as random monoallelic... Read More

Characterizing the Relationship between Ecological Niche and Allopolyploidy in Plants

Abby Jackson-Gain : Integrative Biology, Geology Summer 2020

I am interested in the relationship between hybridization in plants and preferences those plants have for specific environments. When two plants hybridize, creating a new hybrid species, we often observe those new hybrids occupying broader ranges and being able to tolerate a wider array of environmental conditions. I am interested in how widespread this pattern is and... Read More

Exploring Methods for Reducing Uncertainty in Determining the Bulk Density of Soils

Yuan Lin : Atmospheric Science Summer 2020

Human-induced climate change is a modern environmental challenge that poses serious threats to both natural ecosystems and human society as it exists today. As a result, scientists have examined carbon sequestration in soils as a climate mitigation strategy that could lower greenhouse gas concentrations in the atmosphere. This approach involves quantifying rates of... Read More

Investigating Variation in Bacteriophage Plaque Morphology

James Lu : Molecular and Cell Biology Summer 2020

My research project stems from an early observation in our lab where a lytic phage called SHL created plaques (zones of bacterial clearance) with highly variable sizes. This is interesting because it is expected that a homogenous population would produce plaques of relatively similar sizes because they all have the same genetic makeup. Based on past experiments I have... Read More

Cataloging the Water Sorption Properties of Metal Organic Frameworks

David Michael : Chemistry Summer 2020

Approximately 785 million people worldwide lack access to safe drinking water. Though often ignored as a viable source of drinking water, Earth’s atmosphere contains 13 sextillion liters of gaseous water. In recent years, advances in materials science have bred a new class of materials, known as metal organic frameworks (MOFs). Upon judicious construction, MOFs can... Read More

Understanding the effect of aging on the lactate receptor GPR81 and metabolic inflexibility

Marvin Miller : Cell & Developmental Biology Summer 2020

The primary objective of this research proposal is to examine the effect of aging on the lactate receptor GPR81 and metabolic inflexibility. GPR81 gets activated by lactate among the series of short-chain carboxylic acids and reduces intracellular cAMP levels that influence the inhibition of fatty acid transporter and lipolysis (Ahmed, Kashan, et al., p315). Metabolic... Read More

Elucidating Genetic Interaction Networks of Post-Transcriptional Regulators in Yeast

David Noble : Data Science Summer 2020

Post-transcriptional regulation is vital for cell survival and proliferation in diverse environments, but little is understood about the underlying regulatory networks or their mechanisms. Regulation of mRNA expression is an essential process in cells that involves RNA binding proteins targeting mRNAs to change their localization, expression, and stability. These... Read More

Characterizing Photomultiplier Tube Nonlinearity for Radiation Detection

Allison O'Brien : Physics Summer 2020

In the radiological sciences, photomultiplier tubes (PMTs) are often used for measuring scintillation, light emitted from certain materials in the presence of radiation. For example, the neutron response of organic scintillating materials is currently being measured at LBNL using photomultiplier tubes. When incident neutron radiation strikes an organic scintillator,... Read More

RNA-seq analysis of Mimulus guttatus copper tolerance

Alex Ripperton : Molecular Environmental Biology Summer 2020

Populations of Mimulus guttatus commonly known as yellow monkeyflower, have rapidly adapted to grow on soils contaminated with high levels of copper in regions of Northern California. I’m interested in better understanding the evolutionary mechanism that allowed this organism to adapt so quickly to these extreme conditions at a genetic level. Using RNA sequencing data... Read More

Investigating the role of how S1PR3 promotes the release of CGRP

Ricardo Silva : Cell & Developmental Biology Summer 2020

Psoriasis is an autoimmune disease that causes skin cells to grow at an abnormal rate. This disease leads the skin to develop red bumpy patches covered with white scales. Itchiness, burns, and stings are common discomforts associated with the disease. Psoriasis affects 8 million Americans and 125 million people worldwide.

Currently, antihistamine does not treat... Read More

Comparison of conditions supporting coral reef structure in islands throughout the Pacific

Blake Stoner-Osborne : Molecular Environmental Biology Summer 2020

Global change occurs at unprecedented rates within the Anthropocene and the drastic changes to coral reef ecosystems around the globe are unparalleled. Long-term ecological monitoring datasets from coral reefs in the Carribean and Indo-Pacific regions contain key information for assessing modern changes to tropical reef ecosystems. Abundant data on oceanographic... Read More

Chemosensory Adaptation to Host Specialization in Herbivorous Drosophilidae

George Wang : Molecular & Cell Biology, Nutritional Sciences - Toxicology Summer 2020

Herbivory is a key innovation that accounts for half of all insects and one-third of all living orders. It is believed that loss-of-function in chemoreceptor genes is the driving force behind the transition to herbivory in insects, but the underlying mechanisms are still poorly understood. One such chemoreceptor gene within the ionotropic receptor (IR) family, IR92a,... Read More

Examining the morphological development of a new tripartite landmark in human posterior cingulate cortex

Ethan Willbrand : Psychology, Molecular and Cell Biology Summer 2020

The human cerebral cortex contains ridges (gyri) and indentations (sulci) that other species do not have — especially in locations that are expanded in humans such as the posterior cingulate cortex (PCC). In PCC, there is confusion regarding sulcal definitions and nomenclature, which affects interpreting sulcal-functional correspondences. Recently, we reduced confusion... Read More

Investigating Lithium Plating Detection in Graphite/NMC Lithium-Ion Batteries

Brendan Wirtz : Chemical Engineering Summer 2020

Lithium-ion batteries are a prominent energy storage technology with widespread applications in electronics and electric vehicles. Using Li-ion batteries in electric vehicles is especially attractive to decrease reliance on fossil fuels for transportation, but slow charge times dissuade consumers from purchasing them. A barrier to faster charging is a phenomena... Read More

Investigation of Therapeutic Efficacy of EGFRvIII-targeting CAR-NK cells against Glioblastoma in vitro and in vivo

Ashley Yang : Molecular and Cell Biology, Public Health Summer 2020

Glioblastoma (GB) is the most common and aggressive brain tumor in adults, composed of a microenvironment that suppresses the defense function of T-cells and Natural Killer (NK) cells. Chimeric antigen receptors (CARs) have recently become a robust form of adoptive cell therapy, also known as cellular immunotherapy. Studies on GB treatment using CAR-NK cells have... Read More

Detecting Aquifer Characteristics of Groundwater-Dependent Meadow Ecosystems in the Northeastern Sierra Nevada

Allison Zau : Geology Summer 2020

While riparian meadows encompass <1% of the forested area in the Sierra Nevada, they provide key access to near-surface groundwater, sustaining the productivity and biodiversity of montane ecosystems. However, rising temperatures are depleting critical snowpack, which acts as long-term water storage. Conservation organizations have already classified 40-70% of... Read More