Evaluating the Role of Trehalose in Desiccation Tolerance in Saccharomyces Cerevisiae
Desiccation tolerance is an organisms ability to withstand removal of as much as 95% of its intracellular water and be able to resume normal metabolism upon rehydration. However the molecular basis for tolerance is not completely understood. Budding yeast, Saccharomyces cerevisiae, is one of the rare species that exhibit this amazing trait and is an excellent organism to study desiccation tolerance. Upon desiccation, yeast, like other desiccation tolerant organisms, accumulates the disaccharide trehalose. However, mutants that are unable to make trehalose exhibit significant tolerance, suggesting the existence of other molecules that help promote tolerance. My project this summer is to identify additional molecules that cooperate with trehalose and to examine the roles of these genes in desiccation tolerance. This research will provide an understanding of the molecules necessary for tolerance, which can used in biomedical applications, like safely desiccating red blood cells for long term transportation and storage.
Message to Sponsor
- Major: Molecular and Cell Biology: Developmental Genetics
- Sponsor: Thye Fund
- Mentor: Douglas Koshland, Molecular and Cell Biology