Elucidating the structure and function of lens protein Lim2
The human lens is made up of two types of cells: a monolayer of lens epithelial cells, and its differentiated progeny, lens fiber cells. The differentiation process is a complex sequence of events in which lens epithelial cells slowly lose all their organelles, and elongate into lens fiber cells. There is a lens membrane protein called Lim2 that appears to exist only in lens fiber cells, and not in lens epithelial cells. Lim2 is known to be critically important for maintaining the integrity of the lens, and its role will be the focus of my summer research project. I will be conducting various in vitro experiments to determine the structure and functional domain of this protein.
Message to Sponsor
- Major: Molecular and Cell Biology
- Mentor: Xiaohua Gong, Vision Science/Optometry