Inhibition of NRAS mutant malignant melanoma through targeting long non-coding RNA in vitro and in vivo
Melanoma is among the most common and lethal forms of cancer and its incidence has greatly increased in the last 30 years. Long non-coding RNAs (lncRNA) are a class of epigenetic regulatory molecules important to cancer development and progression, and can serve as tumor markers or even targets for therapy. My research is focused on two novel lncRNA important for the survival of NRAS mutant malignant melanoma. I aim to verify the effects of these lncRNA, as well as demonstrate that we can inhibit melanoma cell growth both in vitro and in vivo through targeting these lncRNA. Additionally, I hope to characterize the mechanisms of action of these lncRNA so see if they are viable targets for therapy.
Message to Sponsor
- Major: Molecular and Cell Biology - BMB and Public Health
- Mentor: Susana Ortiz