SURF

Henry Kilgore

Unveiling Bio-activity: A Computational Approach to Bioaction of Leukotriene B6

Inflammation is the bedrock of the bodys chemical and biological responses to deleterious agents. Whether the negative stimuli is of biological, physical or chemical origin an inflammatory response is critical to the healing process, as it mediates the removal of a negative stimulus and promotes restoration of homeostasis to local physiological conditions. The experimental compound leukotriene B6 (LTB6) is postulated to be of an anti-inflammatory nature, given its structural similarities to other well studied and fish oil derived -3 compounds serving to temper immune and inflammatory responses. Using quantum mechanical methods which allow for the development of large scale models I will evaluate the structural features and physical properties which confer the biological behavior of LTB6. The calculations I shall perform will allow for the development of relationships between the structure of LTB6, other -3 signaling molecules and the enzymatic receptors which tie physiological responses to the presence of -3 compounds.

Message to Sponsor

As far back as I can recall I have had a passion for understanding the mechanisms which allow universe around us to proceed. Any opportunity in which I can learn and discover more about the proceedings of the natural world is both inspiring, stimulating and immensely fun. It is with great joy that I take up this task, and my sincerest gratitude goes out to the Rose Hills Foundation for making this fellowship a reality for me.
  • Major: Chemistry
  • Sponsor: SURF Rose Hills fellow
  • Mentor: Karsten Gronert, Vision Science