Evaluation of Post ACL Injured Knees
Injuries to the ACL are very common in the young and active population, and this can often lead to posttraumatic osteoarthritis (OA), sometimes as early as in their third decade of life. Like idiopathic OA seen in older individuals, posttraumatic OA causes pain, impaired function, and overall decreased quality of life, but occurs at a much younger age after injury. ACL injuries are commonly treated with surgical reconstruction of the ligament, replacing the torn ACL with a graft. However, surgical reconstruction does not perfectly correct for tibiofemoral joint kinematics. Moreover, these subtle changes in knee kinematics can lead to early joint degeneration overtime. Since the mechanism behind OA development after ACL injuries is poorly understood, there is little development of preventive measures that could help this particular population. The purpose of my project is to correlate biomechanical alterations after ACL injuries and articular cartilage changes to better understand how ACL injuries can lead to OA. This is a translational research study in the field of sports medicine and arthritis that can lead to the development of therapies to treat or delay the onset of post-traumatic OA after ACL injury.
Message to Sponsor
- Major: Microbial Biology
- Sponsor: Rose Hills
- Mentor: Xiaojuan Li, Radiology and Biomedical Imaging (UCSF)