The Functional Effects of Troponin I Phosphorylation in Slow and Fast Rat Skeletal Muscle
My research is looking into the effects of chemical modification of the skeletal muscle protein troponin I. The troponin complex is composed of three subunits (troponin I, C, and T) that combine to regulate the strength of skeletal muscle contraction. Past research has shown that modification of troponin I by specific enzymes can increase the amount of force heart muscles produce. My project will focus on the effects of such enzymes in skeletal muscles. Because the structure of troponin I in skeletal muscle varies slightly from the structure found in cardiac muscle, we expect to see a deviation in the effects on force production. My findings could help provide insight on the mechanism by which Beta-blocking drugs reduce muscle strength. Over the summer I will be testing to see if specific enzymes have effects on skeletal muscle. If these enzymes do act on skeletal troponin I, then I will test to see how such modifications effect the force production.
Message to Sponsor
- Major: Integrative Biology
- Mentor: Steven Lehman, Integrative Biology