The Role of Nonhematopoietic Cells in Tuning Natural Killer Cell Responsiveness
In the Raulet lab, we are interested in studying the ability of a subset of innate lymphocytes called Natural Killer (NK) cells to respond to stimulation (responsiveness). NK cell responsiveness mainly depends on their ability to engage with a family of proteins called Major Histocompatability Complex Class I (MHC-I) molecules commonly expressed throughout the body. However, whether a particular cell type is responsible for setting the levels of NK cell responsiveness is still outstanding. During the summer, I will develop part of a bigger project aimed in identifying the cellular component important for tuning the responsiveness of NK cells particularly focusing on the role of MHC-I on non-hematopoietic cells (nHCs). Once we establish the cellular type involved in tuning NK cell responsiveness, we could be able to modulate NK responsiveness towards hyper- and hypo-responsivity, to be applied in cancer therapies or for the improvement of graft rejection.
Message to Sponsor
- Major: Molecular and Cell Biology: Immunology and Pathogenesis
- Sponsor: Rose Hills Foundation
- Mentor: David Raulet, Molecular and Cell Biology