Identifying Key Components of Regeneration in Drosophila Imaginal Discs
In the human body, the liver is the only organ that can regenerate following substantial damage. But if all cells contain the same genetic information, how is this function unique to the liver? This summer I will study regeneration in the wing imaginal discs of developing Drosophila larvae. My goal is to develop a system that introduces localized cell death in these discs. Following cell death, I will visualize the amount and location of cell proliferation in the remaining cells. With this system, I can assess the ability of mutant cells to respond to localized cell death, which will provide insight into what genes, when mutated, disrupt regeneration. By finding which genes affect regeneration, we can gain a better understanding about the cell growth pathway.
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- Major: Molecular & Cell Biology, Public Health
- Mentor: Iswar Hariharan, Molecular & Cell Biology