Displaying 1 - 15 of 15

Detection of Intracellular Pseudomonas aeruginosa

Sarah Alsamman : Molecular and Cell Biology Summer 2016

Pseudomonas aeruginosa is an opportunistic pathogen that most commonly causes infection in immunocompromised individuals or compromised epithelial surfaces such as the cornea. This infectious agent is the leading cause of contact lens-associated microbial keratitis, which sometimes results in vision loss or blindness. I am interested in the mechanisms through which P.... Read More

The neural mechanism of in-group favoritism in rat prosocial behavior

Stella Chen : Molecular and Cell Biology, Psychology Summer 2016

Prosocial behavior is rooted in empathy, or the ability to understand and share the feelings of others. Humans, like many other animals, have been shown to process the pain of in-group and out-group members differently, reflecting strong empathic bias towards one’s own group. Encouragingly, research suggests that positive social interactions with an outgroup member... Read More

NHE8 control on pH homeostasis in RPE cells

Ian Ferguson : Applied Mathematics, Molecular Cell Biology Summer 2016

In the eye, Retinal Pigment Epithelium (RPE) cells are important in maintaining the health of photoreceptor cells. RPE defects can lead to early photoreceptor cell death which is linked to several vision disorders, including Age-Related Macular Degeneration (AMD). The Gong Laboratory has previously linked the protein NHE8, a proton/sodium ion transporter mostly... Read More

Scanning Tunneling Microscopy of Covalent Organic Frameworks

Patrick Forrester : Physics Summer 2016

In the past ten years, scientific interest has grown in the field of two dimensional self-assembled molecular structures because of their promise for flexible nanoscale electronic applications including single molecule sensing, improved photovoltaics, and organic light-emitting diodes. Covalent Organic Frameworks (COFs) are strong candidates for these applications by... Read More

Transcriptional Regulation of Telomerase

Manraj Gill : Molecular and Cell Biology Summer 2016

Human chromosomes end in a repetitive sequence called the telomere. The inability of the DNA replication machinery to fully replicate chromosomes results in progressive telomere shortening with each cell division. Critically short telomeres serve as a signal to stop cellular replication. In this manner, telomeres act as a buffer sequence to prevent loss of genetic... Read More

Cell non-autonomous regulation of the unfolded protein response in aging

Nazineen Kandahari : Molecular & Cell Biology and Public Health Summer 2016

The epidemiology of disease is changing from acute to chronic. A majority of our research and public health efforts have been focused on eradicating infectious diseases when, in fact, chronic diseases are the leading causes of death worldwide. The mortality rate for chronic disease increases exponentially with age, and, with the increasingly aging population, chronic... Read More

Environmental and Social Effects of Agrochemical Use in Taichung, Taiwan

Kimberlie Le : Legal Studies, Molecular Toxicology, Society + Environment Summer 2016

My research is an interdisciplinary study of the effects of agrochemicals on river ecosystems.  I will be travelling the Taichung, Taiwan to conduct my study in an area which predominately farms various fruits and vegetables. I'm interested in looking at the environmental effects of the agriculture on river ecosystems by performing bioassement arrays and looking at... Read More

Relationships Between Lithology, Vegetation, and Landscape Evolution

Colleen Murphy : Geophysics Summer 2016

The ability to understand and predict how landscapes will evolve enables us to mitigate the effects of natural disasters and to act as stewards of the land by taking appropriate conservation and restoration measures when necessary. Currently, the geomorphic transport laws that we use to express this evolution do not quantitatively consider variations in rock types and... Read More

Low Temperature Electrical Transport Measurements of Graphene Aerogels

Kevin Nuckolls : Physics, Applied Mathematics Summer 2016

Carbon-based nanomaterials have been the focus of a myriad of research endeavors within the field of Condensed Matter and Materials Physics for the past few decades. Certain allotropes of carbon, such as single-layer graphene, single-walled carbon nanotubes (SWNTs), and spherical carbon fullerene, have been thoroughly explored in their electrical, thermal, and... Read More

Understanding the neuronal basis of sleep in human using tauopathies as models

Joseph Oh : Molecular and Cell Biology/Neurobiology Summer 2016

The purpose of my research is to investigate the neurobiological basis of sleep disturbances in humans using neurodegenerative conditions associated with signature patterns of sleep changes as a model. Alzheimer’s Disease (AD), Corticobasal Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) are the most frequent tauopathies, neurodegenerative conditions... Read More

Comparative functional analysis of endocytic membrane curvature-sensing BAR domain proteins in cancer and stem cell lines

Jordan Said : Molecular and Cell Biology, Chemistry (minor), Music (minor) Summer 2016

Clathrin-mediated endocytosis (CME) is a highly conserved cellular process responsible for nutrient uptake and membrane recycling in eukaryotic cells. After initiation, clathrin and adaptor proteins are recruited to form a clathrin-coated pit, which ultimately matures into a vesicle that is cleaved from the membrane by the concerted efforts of multiple proteins.... Read More

CRISPR/Cas9-mediated functional screening of proton pumps during development of the Xenopus mucociliary epidermis

Dingyuan I. Sun : Molecular and Cell Biology Summer 2016

Inhibition or mutation of transmembrane proton pumps is associated with human airway diseases, such as pneumonia and cystic fibrosis. However, the underlying molecular mechaisms remain poorly understood. A mucociliary epithelium lines the upper repiratory tract and clears the airways from inhaled pathogens. Inhibition of the proton pump gastric H+/K+ATPAse (ATP4a)... Read More

Molecular determinants of DENV NS1-mediated endothelial barrier dysfunction

Edwina Tran : MCB Infectious Diseases and Public Health Summer 2016

Dengue virus (DENV) is a mosquito-borne flavivirus that causes up to 390 million infections every year, resulting in 96 million cases of disease globally. Infection with any of the four serotypes of dengue can result in inapparent infection, dengue fever, or severe forms of the disease associated with vascular leak leading to shock. DENV non-structural protein 1 (NS1)... Read More

Characterizing Expression of CtBP Isoforms

Susan Wang : Molecular and Cell Biology Summer 2016

Many factors come into play in the course of an organism’s growth and development, one of which is the transcriptional coregulator C-terminal Binding Protein (CtBP). CtBP has been characterized in a variety of developmental pathways, including the TGF-beta and WNT pathways, and has been shown to produce growth abnormalities when studied in drosophila melanogaster. I... Read More

Understanding the Dynamics of the ALPHA Antihydrogen Trap

Mike Zhong : Physics Summer 2016

Due to its scarcity on Earth (and as far as we know, the observable Universe), very little is known about antimatter, partner particles of equal mass but opposite charge as normal matter. The ALPHA collaboration at CERN in Geneva, Switzerland is one of the world’s most advanced antimatter experimental sites. A cylindrical magnetic trap is used to trap antihydrogen... Read More