Displaying 1 - 22 of 22

Reprogramming of Müller Glial Cells by Adeno-Associated Viral mediated delivery of split dCAS9-VP64-MS2-p65

Annika Anderson : Molecular and Cellular Biology (Neurobiology), Gender and Women's Studies Summer 2017

Retinitis Pigmentosa (RP) is a set of genetically inherited neurodegenerative disorders that leads to degeneration of photoreceptor neurons and loss of vision. While onset of RP can be detected early, there are currently no treatments to prevent disease progression. Cellular reprogramming is a promising approach to replenishing photoreceptors after retinal degeneration... Read More

Silk Gene Expression Associated with Loss of Web-Building in Tetragnatha Spiders

Cory Berger : Integrative Biology Summer 2017

Discovering how traits evolve or are lost is key to understanding the processes underlying biodiversity. Web-building is an ancestral trait in orb-weaving spiders, but several taxa have secondarily lost the ability to build webs. Among the long-jawed spiders of the genus Tetragnatha, there are species that exhibit a range of web-building phenotypes, including the total... Read More

Investigation of the Effects of LisH Domain Proteins on the Drosophila Melanogaster Histone Cluster

Andrew C. Lu : Molecular and Cell Biology Summer 2017

Many tandemly repeated histone gene clusters exist in the Drosophila Melanogaster genome and are subjected to complex regulation during the cell cycle. However, the exact mechanism of this regulation remains elusive. Using a variant of the CRISPR/Cas9 system, we have developed a DNA-pulldown technique that, when coupled to mass-spectrometry, is capable of identifying... Read More

Development of Ferritin-iron Redistribution to Ion Channels (FeRIC) Technology

Chelsey Campillo Rodriguez : Molecular & Cell Biology- Neurobiology Summer 2017

For decades, researchers have been experimenting with tools used for neural stimulation, modulation, and therapy. A greatly used and helpful tool includes optogenetics, which utilizes light waves to control cells expressing light-sensitive channels. While optogenetics is not an invasive recording technology, due to its dependence on visible light it cannot penetrate... Read More

Diurnal variation in robotic observations of carbon export in California coastal waters

Beth Connors : Marine Science, Integrative Biology Summer 2017

One of the most interesting components of the global carbon cycle is the movement of carbon from the atmosphere to the deep ocean, where it is deposited as particulates, a process called the Biological Carbon Pump (BCP). The BCP combines physical oceanography and biology, as the majority of the carbon dioxide that is pulled from the atmosphere into our oceans for... Read More

Understanding the Effect of a Necroptotic Cancer Vaccine on Anti-tumor Immunity

Emily Duan : Molecular and Cell Biology; Economics Summer 2017

The activation of the adaptive immune system in host-tumor interaction mediates the efficiency and strength of the host anti-tumor response. Necroptosis, a form of programmed cell death, has the ability to moderate the development of antitumor tolerance versus immunity due to its pro-inflammatory properties. However, in what ways and to what extent do the products of... Read More

ILC2 Colonization and Asthma Predisposition

Alexandra Dubinin : Molecular and Cell Biology Summer 2017

Respiratory infections in infancy are known to increase the risk of developing asthma in later life.  One possible explanation is that viral infections during vulnerable periods of development alter immune cell establishment leading to lifelong changes favoring asthma. My research involves tracking the developmental pattern of a particular immune cell, ILC2, with the... Read More

Identification of Anti-CRISPRs for Genome Editing Safety

Bridget Hua Bui : Molecular & Cell Biology Summer 2017

Since the discovery of the CRISPR-Cas adaptive immune system in prokaryotes, Cas9 proteins have been used as a genome editing tool in a wide variety of organisms and promise to provide new solutions to long-standing, unsolved problems in human disease. However, despite the great potential CRISPR technology holds, concerns remain about the risk of unwanted edits in the... Read More

Evaluating thermodynamic equations of state for numerically simulated materials

Katherine Latimer : Physics, Chemistry Summer 2017

Hi! My name is Katie and I'm majoring in Physics and Chemistry here at Cal. I am really excited about my research this summer because it combines those two subjects, which I love, as well as some math and computer science, which are also fun. My work falls under the scope of the Materials Project, a collaboration at Lawrence Berkeley National Laboratory that runs... Read More

Investigating the Role of Ras-like GTPases in TORC2 Localization of Saccharomyces cerevisiae

Iris Li : Molecular & Cell Biology Summer 2017

The Target of Rapamycin (TOR) is a protein kinase involved in many aspects of cell physiology. Because of its importance in regulating growth, TOR has been central to metabolic and cancer research for years. Saccharomyces cerevisiae contains two paralogs of TOR, Tor1 and Tor2, which exist in their respective multi-subunit complexes TORC1 and TORC2. TORC2 has been found... Read More

Investigation of Parrondo's Paradox

Julia Lipson : Applied Mathematics Summer 2017

Imagine a person plays two games, Game A and Game B, each with a higher probability of losing than winning, in some sequence. A possible sequence might be Game A, followed by Game B, followed by Game A, etc. Surely, playing any sequence of these two games will result in an overall loss. Against intuition, this turns out not to be the case. In fact, by playing these... Read More

Treating Huntington's Disease by Autophagy

Dawei Liu : MCB Immunology Summer 2017

Huntington’s disease (HD) is a neurodegenerative disease resulting from accumulation of neurotoxic protein aggregates in the brain. The leading cause is the abnormal expansion of glutamine (polyQ) in the huntingtin protein (HTT). A major quest in this field is to develop strategies to clear the polyQ HTT aggregates. Autophagy is an essential pathway for cellular... Read More

Effectiveness of Iron Oxide Microlites as Bubble Nucleation Sites in Rhyolitic Melts

Eva Lopez : Geophysics Summer 2017

Investigating the conditions that allow for bubble nucleation and bubble growth is significant for improving our understanding of volcanic eruptions and forecasting how they evolve over time.  This research investigates how the presence of Iron Oxide (FeO) microlites may influence the nucleation of bubbles in rhyolitic melts as a function of temperature and at room... Read More

Understanding the Wnt Signaling Pathway through ALM Polarity

Faustine Luo : Molecular & Cell Biology Summer 2017

The Wnt signaling pathway is an evolutionarily conserved signal transduction pathway that regulates important developmental processes such as cell fate, cell migration, cell polarity, and cell proliferation when activated by secreted Wnt glycoproteins. Mutations in Wnt signaling or Wnt genes have been shown to lead to specific developmental defects, including many... Read More

Overruled Cones of Permutation Equivariant Quantum K-theory

Charlie Reid : Mathematics Summer 2017

In string theory we are interested in the set of world sheets swept out by strings moving through spacetime that satisfy certain equations of motion. This set, called a moduli space, is mysterious and complicated but it possess a lot of structure that is not apparent at first glance. I study this moduli space using a mathematical tool called K-theory which leads to... Read More

Investigating Pathogen Induced Behavioral Changes in Drosophila melanogaster

Quinn Spencer : Molecular & Cell Biology Summer 2017

Entomopthera muscae is a fungus that infects flies that can induce behavioral changes and subsequently cause morbidity Drosophila melanogaster. However, the mechanism behind this drastic modification is still largely unknown. My research aims to find a way to modify and flourescently tag a gene in the fungus using CRISPR/Cas9, which may allow us to better understand... Read More

Characterizing the Dynamic Regulation of the K2P ion channel, TRESK

Ian Tayler : MCB Neurobiology Summer 2017

An essential component to better understanding cellular electrical signaling is to address how the resting membrane potential in neurons is established and modified to affect excitability. Two-pore domain potassium (K2P) ion channels are directly involved in this process and comprise a unique protein family that is essential for the maintenance of this resting membrane... Read More

Roles of Unc93B1 in TLR9 regulation beyond trafficking

Brian Woo : Molecular and Cell Biology; Statistics Summer 2017

The Toll-like receptor (TLR) family is a key component of the host innate immune response to foreign microbes. In the cell, TLRs localized to endolysosomes (termed “intracellular TLRs”) recognize microbial nucleic acids, and recognition of these microbial products then invokes an immune response to a myriad of bacterial and viral pathogens. One regulator of... Read More

Dyskeratosis Congenita shelterin mutations in hESCs

Shannon Wu : Molecular and Cell Biology Summer 2017

Telomere maintenance and protection is performed by the six-protein complex called shelterin. Shelterin defects may lead to telomeropathies like Dyskeratosis Congenita (DC), a rare but severe disease with poor clinical outcomes. Recently, whole exome sequencing studies of DC patients have identified mutations in the gene locus of the shelterin component, TIN2. By... Read More

Understanding factors that influence self-reactive thymocyte fate

Jaewon (Jenny) Yoon : Molecular and Cell Biology, Immunology Summer 2017

Some thymocytes, or T cell precursors, have the ability to respond to self-antigens. If these thymocytes were to leave the thymus, they would develop into conventional T cells with the potential to drive autoimmune diseases. To prevent self-reactivity, these cells are often deleted from the repertoire through a process known as negative selection. Some, however,... Read More

Investigating the influence of Drosophila DNA bending proteins, HMGD/HMGZ, on P element transposase activity

Tong Zhang : Molecular and Cell Biology, Bioengineering Summer 2017

DNA transposable elements are mobile genetic elements that can move through out a host genome by the action of an encoded DNA transposase. The activity of several DNA transposases is significantly stimulated by DNA bending proteins, presumably promoting correct assembly of the transposase upon the DNA transposon ends (i.e. Mu transposase , RAG1/2, …etc). While... Read More

Inhibition of NRAS mutant malignant melanoma through targeting long non-coding RNA in vitro and in vivo

James Zheng : Molecular and Cell Biology - BMB and Public Health Summer 2017

Melanoma is among the most common and lethal forms of cancer and its incidence has greatly increased in the last 30 years. Long non-coding RNAs (lncRNA) are a class of epigenetic regulatory molecules important to cancer development and progression, and can serve as tumor markers or even targets for therapy. My research is focused on two novel lncRNA important for the... Read More