Displaying 1 - 19 of 19

DT-MRI Visualization of the brain’s optical networks to understand MS Pathology

Amit Akula : Computer Science Summer 2016

While researchers have not been able to fully characterize the pathology of multiple sclerosis (MS), conventional Magnetic Resonance Imaging (MRI) techniques  have been the “gold standard for the diagnosis and monitoring of MS” (Guglielmetti, Lassmann). Using advanced MRI techniques, such as diffusion weighted imaging, and specifically spherical deconvolution... Read More

Relationship between wear and nano-mechanical properties of Polycarbonate Urethane (PCU)

Sofia Arevalo : Mechanical Engineering Summer 2016

Polycarbonate Urethane (Bionate, PCU), a medical grade polymer, is utilized in the orthopedic industry as a load bearing system due to its superior mechanical properties and biocompatibility. However, adhesive/abrasive wear of polymers in vivo can lead to osteolysis (bone loss) and subsequent aseptic loosening of implants, severely limiting their overall lifetime. This... Read More

Specialization of the Human Mediator Complex: How Does This Happen?

Maryia Barnett : Biochemistry and Molecular Biology Summer 2016

Misregulation of cell differentiation often leads to pathological cell fate and frequently employs mechanisms that alter gene expression. There are multiple levels of transcriptional regulation. The focus of my research is one of the subunits of the Mediator complex, MED12 and its paralogue MED12L. The Mediator is known as a general transcription factor, and so it is... Read More

Electronic Transport in NbSe2-NbSe3 van der Waals Heterostructures

Joey Barreto : Physics, Computer Science Summer 2016

Today's technology has allowed for significant advances in the fields of condensed matter physics and materials science. In recent years scientists have been able to consistently isolate high quality, atomically-thin layers of various crystals and compounds, beginning with graphene (a single sheet
of carbon in a hexagonal pattern) in the mid-2000s. While there has... Read More

The effects of heating on the ejecta of black hole-neutron star merger events

Dhruv Desai : Physics/Applied Math Summer 2016

Black hole-neutron star (BH-NS) mergers are remarkably exciting events to model, as they are a source of gravitational waves, same as those discovered for the first time by Advanced LIGO earlier this year. BHNS mergers are binary systems that consist of a black hole (BH) and a companion neutron star (NS), which under sufficient conditions, falls into the BH. After the... Read More

Identification of solid phases transition in BaFe2As2 using Resonant Ultrasound Spectroscopy

Kirk Duran : Physics and Applied Math Summer 2016

Superconductors are materials that exhibit the phenomenon of zero electrical resistance below a certain temperature. Some pure metals are superconductors, but only at very low temperatures.
But over the last few decades some interesting materials have been discovered that super-conduct at “high temperatures”, up to about ­200°C. This is still far below room... Read More

Effects of Calorie Restriction and Mimetics on Protein Translation Rates In Vivo by a Novel Tandem Mass Spectrometric Method

Chase Garcia : Nutritional Science - Physiology and Metabolism Summer 2016

Caloric restriction (CR), defined as under-nutrition without malnutrition, has been shown in a variety of organisms to increase maximal lifespan upwards of 70%. CR also been shown to have other health benefits not limited to reduced carcinogenesis, increased insulin sensitivity, and reduced cardiovascular disease risk. There are several theories as to how this works,... Read More

Unsupervsied Deep Multimodal Learning for Object Detection

Jacob Huh : Electrical Engineering and Computer Science Summer 2016

Recent advances in the artificial neural networks have shown immense success in the computer vision field. While supervised learning tasks in object detection has shown to be a feasible task,  the necessity of the supervision in the task is not observed in humans. Despite the fact that object Information is a unison of all senses,  currently, object detection tasks are... Read More

Electrophysiological Recordings of Sleep in the Fur Seal

Jessica Kendall-Bar : Marine Science and Integrative Biology Summer 2016

Marine mammals, after centuries of convergent evolution, have evolved striking cognitive similarities to humans. However, due to the logistical challenges inherent in neurobiological studies with these creatures, our knowledge of the chemicals involved in fundamental behaviors remains limited. My study will examine the concentrations of glutamate, a major... Read More

Non-Equilibrium Protocols for Optimizing Self-Assembly Yield

Ramin Khajeh : Physics Summer 2016

Self-assembly is the spontaneous organization of components into ordered structure, ubiquitous in materials science and biology. Many essential structures in biology, such as the ribosome or virus shells, organize themselves into ordered structures with surprisingly high efficiency. Despite progress, there is not a comprehensive theory to predict the most likely... Read More

Role of endothelial rae-1ε in NKG2D dependent tumor immunosurveillance

Alexander Kim : Molecular, Cell Biology Summer 2016

Cancer refers to a group of currently incurable diseases characterized by the unchecked proliferation of abnormal cells in the body, resulting in the growth of tumors. Today, cancer remains the second leading cause of death in this country. Most current cancer therapies are highly toxic and often only partially effective, highlighting the need for a greater... Read More

Understanding how the α-arrestin Rog3 plays a role in negatively regulating GPCR Ste2

Rebecca Kuan : Molecular and Cell Biology Summer 2016

G protein-coupled receptors (GPCRs) are plasma membrane localized receptors found in eukaryotic cells. GPCRs are common targets of pharmaceutical drugs because they mediate cellular responses to hormones, neurotransmitters, and environmental stimulants and are also involved in vision, olfaction, and taste. An important aspect of GPCR biology is negative regulation, or... Read More

Investigating the role of ANGPTL5 in the regulation of lipid metabolism

Mei Lan Li : Chemical Biology Summer 2016

Obesity, as a result of excess triacylglycerol accumulated in white adipose tissues, is an established risk factor for many metabolic diseases, such as type 2 diabetes. Studying the lipolytic effects of proteins contributes to the development of anti-obesity and anti-diabetic agents that can potentially control adiposity and improve insulin sensitivity. Angiopoietin-... Read More

Beta-Catenin as a Mechanotransducer in Skin Morphogenesis

Grant Schroeder : Integrative Biology Summer 2016

Despite a deep understanding of many of the molecular components involved in organ development, recreating complex tissues from undifferentiated cells has proven difficult in the field of regenerative biology. For instance, current skin culturing techniques in clinical settings fail in yielding operational hair follicles and sweat glands, creating problems for patients... Read More

Synthesis and Reactivity of Actinide-Guanidinate Complexes

Angela Shiau : Chemistry Summer 2016

Organometallic transition metal chemistry is an important cornerstone of chemical research, as studies have led to the development of important catalysts and deeper understanding in the bonding of elements in the entire periodic table. Analogous chemistry with the actinide elements, however, has been relatively unexplored in comparison. Contributing to this lack of... Read More

Ectopic Kinetochore Formation and Endogenous Centromere Dysfunction due to the Over- Expression of CENP-A

Andrew Song : MCB (Neurobiology) & Spanish Double Major & BioEngineering Minor Summer 2016

Chromosome instability (CIN), a form of genomic instability, is a hallmark of many human cancers. However, the exact mechanisms contributing to CIN in cancers are not completely understood. The centromere, a unique chromosomal domain required for kinetochore formation and faithful chromosome segregation, is a plausible source of CIN as its misregulation has been... Read More

Synthesis of a novel anthracene spacer for incorporation in supramolecular M4L6 assemblies

Alexios Stamoulis : Chemical Biology Summer 2016

The catalytic profile of supramolecular hosts is analogous to that of most enzyme active sites and biological chaperones, which provide both entropic and enthalpic incentives for rapid and reversible substrate encapsulation into their hydrophobic cavities and catalyze reactions by stabilizing transition states. So far, the Raymond group has made significant advances in... Read More

Testing TES Bolometers at 100 mK

Leo Steinmetz : Physics, Astrophysics Summer 2016

Cosmic inflation is a theory that expands on the Big Bang model of the early universe to explain some confusing astrophysical observations. A major next step for physical cosmology is to find direct evidence of inflation. Theoretical cosmologists predict that inflation left patterns in the oldest light in the universe, the Cosmic Microwave Background (CMB), so the CMB... Read More

Vitamin A Metabolism in Adipose Biology

Milena Tintcheva : Molecular Environmental Biology Summer 2016

In the Napoli Lab we study metabolism of Vitamin A, specifically the active metabolite all-trans Retinoic Acid and its role in adipose tissue biology. Retinoic Acid is an important factor for embryonic development, eye health, adipogenesis (fat cell development) and myogenesis (muscle differentiation) as well as the activation of many other genes. My project focuses on... Read More