Displaying 1 - 18 of 18

Stable isotope analysis of travertine carbonates

Holly Barnhart : Environmental Earth Science Summer 2018

For SURF 2017, I studied a travertine fissure ridge in Bridgeport, California to characterize trace element partitioning between thermal spring water and travertine carbonates. I will further analyze this system to establish an empirical temperature-oxygen isotope relationship for regional paleotemperature reconstruction. For use in paleoclimate reconstruction,... Read More

Defining the transcriptional regulation of ATF5 isoforms during mitochondrial stress across multiple cell types

Hannah Chi : MCB Neurobiology and Ethnic Studies Summer 2018

Mitochondria often decline in function as a normal part of aging. However, mitochondrial dysfunction often has severe consequences and has been linked to neurodegenerative diseases, cancer and infection. Understanding the ways in which mitochondria recover when exposed to proteotoxic environments is therefore a crucial element in constructing better novel treatments to... Read More

Understanding the mechanism of NK cell inhibitory receptor Ly49A variegated expression

Susanna Ming-Yu Dang : MCB: Genetics, Genomics & Development Summer 2018

Lymphocytes are a type of white blood cell that are essential to the function of vertebrate immune systems. Lymphocytes include Natural killer (NK) cells, an important component of the innate immune system. NK cells function through families of stimulatory and inhibitory receptors, providing early response to viral infections and tumor development. In mice, Ly49 C-type... Read More

Investigation of the Internalization of Dengue Non-Structural Protein 1

Trent Gomberg : Molecular and Cell Biology Summer 2018

Dengue virus is an arbovirus that affects infects as many as 390 million individuals annually. Up to 96 million individuals express symptoms which range from flu like uncomplicated dengue fever to life threatening cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), the latter being characterized by severe vascular leak and dysfunction of endothelial... Read More

Hyperpolarized Magnetic Resonance Zinc Probes for Prostate Cancer Detection and Risk Stratification

Andrew Hong : Chemistry Summer 2018

Prostate cancer (PCa) is the most common noncutaneous cancer in men and presents with a heterogeneous disease course ranging from indolent to rapidly progressive, fatal disease. Imaging techniques such as magnetic resonance (MRI) and positron emission tomography (PET) imaging are important for differentiating between these phenotypes and selecting appropriate patients... Read More

Repulsive-force electrostatic actuators for low-cost, scalable mechanical stimulation of cell cultures

Loren Jiang : Bioengineering Summer 2018

I plan to develop a new meso-scale device for the mechanical stimulation of cell cultures using repulsive-force electrostatic actuators that I have helped fabricate and characterize in prior work. Cells live within a dynamic micromechanical environment, sensing and adapting to external mechanical forces, including tension, compression, fluid shear, and hydrostatic... Read More

Finding circuit layout and Hamiltonian to optimize quantum variational eigensolver

Vladimir Kremenetski : Physics/Applied Math Summer 2018

Quantum computers promise tremendous gains in computational efficiency to a number of important areas in STEM. Among these, few are as promising as the ability of quantum computers to simulate atomic-scale (and thus quantum) systems. A specific topic of interest in this area is using the simulations to find the ground state energy of particularly cumbersome energy... Read More

Sign of the times: the lipid signature of a collapsing phytoplankton bloom

William Kumler : Marine Science / Molecular Environmental Biology Summer 2018

Did you know that phytoplankton produce half the world's breathable oxygen? These enigmatic organisms are a vital part of the marine ecosystem and closely connected to our terrestrial world, but there's a lot we don't know about them. This summer, I'll be looking specifically at phytoplankton blooms - dynamic events in which they reproduce rapidly and overwhelm... Read More

Investigating mechanisms of nutrient release by phage lysis

Joseph Maa : Microbial Biology Summer 2018

Bacteria live in complex and diverse communities ranging from marine environments and soils to the human gut. Improving our understanding of bacterial communities is dependent on deepening our knowledge of how interactions between species affect community function and structure. In one specific interaction, phages participate in these bacterial communities by lysing... Read More

Dynamic Load Balancing in Networks Using The Data Plane

Angel Najera : Electrical Engineering and Computer Science Summer 2018

The internet essentially functions like a mailing system, with data packets sent across a network of devices. These devices act like the post offices and shipping warehouses from our regular mailing system. Until recently, modifying the way things ran for each device worked in a similar fashion to training a new worker. In our case, it took years for manufacturers to... Read More

Exploring a shallow landsliding event with a multidimensional stability model

Mariel Nelson : geophysics Summer 2018

Shallow landslides are a primary method of sediment transport and a dominant hillslope erosion process in many steep, soil-mantled landscapes. However, testing models that predict shallow landslide size and location is challenging due to a lack of high resolution datasets that map where landslides occurred following major storms. In February 2017, an intense rainfall... Read More

Controlling Antibiotic Production: Regulation of Secondary Metabolism in Streptomyces

Yein Ra : Microbial Biology, MCB Summer 2018

The study of members of the bacterial genus Streptomyces is motivated by their impressive capacity to produce clinically-applicable secondary metabolites, including antibiotics and anti-tumor compounds. It has been widely observed that the production of these secondary metabolites and natural products by Streptomyces species can be increased when in the presence of... Read More

Investigating Inner Ear Protein TMIE Using Yeast Nanobody Display Systems

Sheila Sharifi : Molecular and Cellular Biology - Immunology Summer 2018

The auditory system is remarkable for its ability to detect sounds across a wide range of intensities and frequencies. The molecular machinery involved in generating this range converts acoustic stimuli into electrical signals transmitted to the brain, a process known as mechanoelectrical transduction. The purpose of this research project is to achieve clarification on... Read More

Development and Integration of MEMS Devices for Submerged Microrobotics: Swimming at the Microscale

Ryan Shih : EECS/Bioengineering Summer 2018

Microelectromechanical systems (MEMS) are sub-millimeter structures that combine electrical and mechanical principles to produce novel sensors, actuators, and transducers for complicated tasks at the microscale. While most MEMS research focuses on devices operating in air, biomedical applications and the parallel growth of microfluidics have stimulated efforts towards... Read More

Application-Based Psychotherapy for Dementia Caregivers

Sab Sikder : Molecular & Cell Biology (Track: Medical Biology & Physiology) Summer 2018

Dementia is a very difficult disease to live with as it can progressively deteriorate the cognitive function of a patient to the tragic point where, for example, friends and family become unrecognizable, and basic tasks—such as walking, eating, using the restroom—require continuous, everyday assistance from family members. However this places a significant physical,... Read More

Biochemical Characterization of a CO-Activated Soluble Guanylate Cyclase (sGC)

Edna Stewart : Molecular and Cell Biology Summer 2018

In mammals, soluble guanylate cyclase (sGC) serves as the primary receptor for the signaling gas nitric oxide (NO). Binding of NO activates the enzyme, which leads to various signaling pathways that regulate many physiological functions, including vasodilation and neurotransmission. Activators of sGC are currently used as therapeutic agents for cardiopulmonary and... Read More

Hydrological controls on the distribution and dispersal of bladderpod shrubs

Dylan Stover : Molecular Environmental Biology Summer 2018

Plant communities respond to disturbances in many ways; with the increase in disturbance events in California such as fires and droughts, these community responses have increasingly led to unexpected shifts in dominant plant species that negatively affect their ecosystems through each species’ ecosystem services. In a drought and fire prone place such as Tejon... Read More

Investigating Cbpb's Role in Bacterial Stringent Response

Jeffrey Wang : Molecular and Cell Biology Summer 2018

Cyclic di-AMP (c-di-amp) is a nucleotide second messenger molecule with an integral role in the pathogenesis of many bacteria; however the physiological roles of this molecule in bacteria have only recently begun to be understood. Bacteria are known to undergo physiological and regulatory changes in response to nutrient starvation. Starvation induces the stringent... Read More