Displaying 1 - 24 of 24

Understanding IRES RNA-mediated mechanisms for controlling Hepatitis C Virus Translation

Samar Bhat : Molecular and Cellular Biology Summer 2018

Under conditions of cellular stress, such as in times of starvation, infection, or exposure to potentially dangerous environmental agents, normal cellular processes are often compromised. One such process involves how the 5’-cap structures of mRNA are used to recruit ribosomes, the cell’s translation machinery, to initiate protein synthesis. When this process is... Read More

Characterizing the Function of Unique KSHV Genes

Nicholas Carey : Molecular and Cell Biology: Immunology Summer 2018

We are studying the eighth human herpes virus; Kaposi’s Sarcoma-Associated Herpesvirus (KSHV). This is a sexually transmitted virus that establishes life-long infections. KSHV does not cause symptoms in most people but is known to cause three types of cancer (Kaposi’s Sarcoma, Pulmonary Effusion Lymphoma, and Multicentric Castleman Disease) in immunocompromised people... Read More

Identifying Regions Responsible for Sex Chromosome Drive in a Non-model Drosophila Species

Percival Chen : Molecular and Cell Biology Summer 2018

Gregor Mendel’s law of equal segregation states that the two copies of each chromosome are transmitted with equal probability to the offspring. However, there are also genes, termed meiotic drivers, that manipulate the genome to be transmitted at greater than 50% frequency. Meiotic drivers have been identified across taxa (including insects, plants, fungi, and... Read More

Construction and Testing the New MAPS Pixel Chips for the ALICE ITS

Ivan Chernyshev : Physics Summer 2018

The ALICE detector at the Large Hadron Collider (LHC) at CERN collides lead nuclei and observes the particles ejected from the collision to study quark-gluon plasma, a highly energetic state of matter that existed during the first microsecond after the Big Bang. ALICE’s current systems have been successful in measuring a variety of aspects of quark-gluon plasma, but... Read More

Investigating Molybdenum Disulfide Quantum Dot Blinking

Elizabeth Coda : Physics Summer 2018

Quantum dots are tiny, semiconducting particles with unique electronic properties that distinguish them from larger particles.  Notably, quantum dots have discrete energy levels. Thus, by changing the size of the dot, the difference between these energy levels change. As the size of a quantum dot decreases, the energy difference increases between the highest and lowest... Read More

Optimizing Bacterial Binding to Nanosheets

Jacqueline Dang : Molecular & Cell Biology Summer 2018

I am working with my SURF mentor on optimizing binding of mannose conjugated nanosheets to E. Coli bacteria by controlling expression of pili. Loop are created on the nanosheet surface in an air-water interface by a rocking mechanism. These loops protrude from the nanosheet bilayer, mimicking glycoproteins and glycolipids that protrude from cell membrane surfaces.Type... Read More

Representation Learning & Collaborative Filtering in Course Recommendation

Matthew Dong : Statistics Summer 2018

Web infrastructure in most schools have remained static in a rapidly evolving society; in particular, variety in course enrollment platforms remains lacking in higher education. To provide greater personalized course guidance to individual students, we will leverage machine learning systems lifted from other domains to the education field to build a recommender... Read More

Developing a New Method of Measuring the magnetoelectric Switching in BiFeO3 at the Nanoscale

Sophia Gaynes : Physics Summer 2018

This summer, I will be working in the Ramesh Group to develop a new method of measuring the magnetoelectric switching in BiFeO3 (bismuth ferrite) at the nanoscale. BiFeO3 is a magnetoelectric multiferroic material meaning that it has coupled and stable electric and magnetic polarization without the presence of an external electric or magnetic field. This material was... Read More

Investigating changes in gene expression that affect heart rate during pregnancy

Catherine Jung : Molecular Environmental Biology Summer 2018

In normal pregnancies, cardiac output increases to accommodate increased metabolic demand. There are changes in pacemaker cells that cause an increase in resting heart rate. Currently, the mechanisms that connect changes in hormones to changes in gene expression in pacemaker cells are unknown. Understanding the mechanisms that lead to an increase in heart rate in... Read More

The Esterification of Boronic Acid Derivatives

Elena Kharitonova : Chemical Biology Summer 2018

Aryl esters are a class of organic molecules that have a wide range of applications. They are common active ingredient of pharmaceuticals, food flavorings, perfumes, and cosmetics. They are useful building blocks for other molecules in synthetic chemistry, structural elements in material science, and components of many biological tools. Traditionally, these esters are... Read More

Stereopsis and Motor Control in a Prehension Task

Alyson Kishi : Molecular and Cell Biology Summer 2018

Precise and coordinated motor movement, such as prehension, is an essential skill for completing everyday tasks. The aim of this study is to quantify the relationship between stereopsis (the ability to see depth) and skilled prehension (the ability to precisely grasp an object). We present objects in a frontal view that minimizes other cues to their shape and ask... Read More

Design and Assembly of a Magnetic Quench Protection System for Alpha-G

Huws Landsberger : Physics Summer 2018

The gravitational behavior of antimatter has critical bearing upon our understanding of particle physics, quantum gravity, and the expansion of the universe. The weak equivalence principle (WEP) states any particle’s gravitational acceleration is the same, conflicting with quantum theory, which imposes limits on the certainty of position and momentum (thus trajectory)... Read More

Doping a 2D Mott Insulator

Ryan Lee : Physics and Mathematics Summer 2018

Some of the biggest technological hurdles come from the existence of electrical resistance in everyday materials, causing a waste of energy. High-temperature superconductivity is a great solution to this problem. High-temperature superconductors can conduct electricity without dissipating any energy and possess many special magnetic properties, making them useful for... Read More

Effect of visual experience on ventral-preferring ganglion cell patterning in the mouse retina

Kayla Maanum : Integrative Biology Summer 2018

Direction-selective ganglion cells (DSGCs) are characterized from other retinal ganglion cells because they generate a higher rate of action potentials when a moving light stimulus passes over the cell in its “preferred” direction than when the stimulus moves in the opposite or “null” direction. Four subtypes of DSGCs have been elucidated, each of which prefer one of... Read More

A Genetic Basis for the Evolution and Regulation of Heart Rate

Ravi Mandla : Molecular and Cell Biology Summer 2018

One of the fastest heart rates in the world belongs to one of the smallest mammals, the Etruscan Shrew. Only weighing around 1.8 grams, this animal has a heart rate of 1511 beats per minute (in comparison, human heart rates are around 80 beats per minute). In contrast, the blue whale has a heart rate of about 8 bpm. This phenomenon of heart rate scaling can... Read More

Hybrid and Catalytic Behaviors of Transition Metal Dichalcogenides

Cameron McBride : Chemical Engineering Summer 2018

The development of nanoscale materials (materials that are around 10-9 meters in size) is something that promises to widely impact fields such as computing, medicine, and energy and change the landscape of technology as we know it. One type of promising nanomaterial is the Transition Metal Dichalcogenide (or TMDC) which is a crystalline nanomaterial made of a... Read More

Characterization of transport parameters

Hien Nguyen : Chemical Engineering Summer 2018

Advancement of lithium-based battery technology is extremely important as demand for safer and higher capacity batteries continues to increase. Commercial lithium-ion (Li-ion) technology has an inherit safety concern as the electrolyte mixture of ethylene carbonate, dimethyl carbonate, and lithium hexafluorophosphate is highly flammable. One way to address this problem... Read More

Identification of IFNγ-inducible Genes Essential in Control of Tuberculosis Infection Using a CRISPR/Cas9 System

Xammy Nguyenla : Molecular and Cell Biology Summer 2018

IFN-γ is a cytokine that has essential immunostimulatory and modulatory roles in innate and adaptive immune responses.  More specifically it is released by host CD4+ T cells and has been shown to be essential in macrophage-mediated control of Mycobacterium tuberculosis.  Many downstream pathways have been proposed, including ones involving inducible nitric oxide... Read More

The Synthesis and Reactivity of a Rhenium Dioxo Species

Alex Oanta : Chemistry Summer 2018

Metal-promoted reactions are frequently utilized in the syntheses of complex organic products that are vital to the pharmaceutical and petroleum industries. With the intention of discovering new, more efficient chemical pathways to otherwise inaccessible or costly organic chemicals, many inorganic chemists devote their careers to the synthesis and study of discrete... Read More

Implications of Landscape Features for Agroecological Strategies on Urban Farms

Sierra Raby : Molecular Environmental Biology Summer 2018

The U.S. food system is plagued by food insecurity, which disproportionately affects poor communities and communities of color. Urban agriculture can help remake food systems and mitigate food insecurity by providing opportunities to grow local, nutritious food. However, urban farms often struggle with pest management, and previous survey research on San Francisco Bay... Read More

Regioselective Silylation of Fluorinated Arenes

Camille Rubel : Chemistry Summer 2018

The substitution of fluorine atoms for hydrogen atoms in drug candidates has been shown to improve the biostability of those molecules. However, few reported methods exist that fluorinate complex organic molecules with high selectivity. An alternate approach to the synthesis of fluorinated drug candidates is the addition of functional groups to compounds that contain... Read More

ReVAS: Extracting and Standardizing Eye Motion Data from Scanning Laser Ophthalmoscopes

Derek Wan : Molecular and Cell Biology (Neurobiology) Summer 2018

Our eyes are never stable even when we attempt to maintain a steady gaze. The characteristics of microscopic eye motion during fixation have been proposed as diagnostic biomarkers for certain neurological and visual disorders. However, the use of scanning laser ophthalmoscopes (SLOs) in clinical and research settings is often limited to rough estimates of fixation... Read More

Synthesis and Testing of Porous, Sulfonated Polymer Systems for Drug Capture

Michael Yi : Chemical Engineering Summer 2018

Chemotherapy is one of the most widely known treatments for cancer, both for its effectiveness yet fatal side effects. Doxorubicin, a common type of chemotherapy drug, has the ability to kill malignant tumor cells, but is limited by the harmful interactions excess molecules cause towards human tissue. Various resins and activated carbons are being tested for drug... Read More

On-surface synthesis of 2D covalent organic frameworks

Eric Yu : Chemistry Summer 2018

A covalent organic framework is a crystalline structure consisting of covalently bonded organic molecules in a porous network. 2D COFs as thin as a single atomic layer are expected to have exotic electronic properties due to reduced dimensionality. My research is focused on several aspects of these novel nano-structures, including their synthesis on metallic substrate... Read More