Displaying 1 - 23 of 23

Topological superconductivity of Weyl Semi-metals

Arman Babkhani : Engineering Physics Summer 2016

The search for superconductors began in the twentieth century as our understanding of quantum physics developed. In the field of condensed matter physics this search is pivotal. My research will focus on investigating the superconductive properties of certain group of semi-metals, known as Weyl semi-metals. These semi-metals are crystals whose low energy excitation was... Read More

Benchtop Characterization of Fetal Membrane Sealants

Sarah Bhattacharjee : Bioengineering Summer 2016

The field of fetal surgery, though it remains the best hope for expecting parents whose child might have dangerous complications, is impeded by the amniotic sac's inability to heal following rupture. The Messersmith Group, in which I work, has proposed both a sealant, which draws inspiration from the chemical properties of the adhesive secreted by mussels to attach... Read More

The role of miR-200 in regulating self-renewing cancer stem cells in Kras lung adenocarcinomas

Claudia Chan : Public Health Summer 2016

Lung cancer is the leading cause of cancer deaths worldwide, with non-small-cell lung cancer (NSCLC) accounting for nearly 80% of the cases. Adenocarcinomas are the most prevalent type of NSCLC among which Kras is the most commonly found mutation that correlates with poor patient prognosis. In our mouse model carrying this oncogenic Kras mutation allele and the... Read More

Projective Representations of the Symmetric Group

Eric Chen : Mathematics Summer 2016

Lately, we have witnessed increased interest in the study of representations of symmetric groups, and in particular, in their projective representations. In a classic paper, I. Schur introduced what are now known as Schur Q-functions in order to calculate these projective characters; combinatorial formulas for these characters are also available in the early works of D... Read More

Interleukin-33 expression by astrocytes in response to neuronal activity

Elliott Chien : Molecular and Cell Biology Summer 2016

Astrocytes, the star-shaped glial cells of the central nervous system, are necessary for synapse formation, which makes the role of astrocytes in brain development particularly interesting as autism and schizophrenia are fundamentally diseases of circuit and synapse formation. Molecular communication between astrocytes and microglia, a second type of glial cell, is an... Read More

The Role of Gpr75 and RANTES in the Beta-Cell Response to Autoimmunity

Justin Choe : Bioengineering Summer 2016

Despite the growing prevalence of diabetes, the exact biological mechanisms leading to the onset of this disease still remain painfully unclear.  Type 1 diabetes in particular is caused by an autoimmune attack to an individual’s insulin secreting beta cells; this cell population cannot be regenerated and an adverse condition known as hyperglycemia ensues.  The immune... Read More

Identifying correlations between transposable elements, genome size, and lifespan

Emily Chong : Integrative Biology Summer 2016

Genome sizes vary greatly across many species and within species, though their biological significance is still poorly understood. Large amounts of eukaryotic genomes are composed of repetitive DNA, whose functions also remain ambiguous, and are often called “junk” DNA. These repeats usually exist in the form of heterochromatin, DNA that is tightly packed as a possible... Read More

Investigating the development of a subject's trained preferred retinal locus in response to a simulated central scotoma

Tiffany Fung : Integrative Biology Summer 2016

Age-related macular degeneration is the number 1 leading cause of blindness in the world. Macular degeneration is a central retina eye disease that leads to the atrophy of photoreceptors in the macular region of the eye and causes vision loss. AMD patients develop a scotoma, a blind spot, in the central part of their visual system. Their fovea, located in the macular... Read More

HST/WFC3 Imaging and Multi-Wavelength Characterization of Edge-On Protoplanetary Disks

Cee Gould : Astrophysics and Physics Summer 2016

This summer, I will be conducting research on an astronomy project involving the data reduction and analytical characterization of several Hubble images of edge-on protoplanetary disks (dust around newly formed stars). This is a topic of interest since the study of pre-planetary systems lends clues to the still unsolved mysteries of the formation of planetary bodies,... Read More

Recombinantly expressed tobacco mosaic virus nanocarrier for chemotherapeutic applications

Kenneth Han : Chemical Biology Summer 2016

Current administration of chemotherapeutics lack specificity and have adverse effects to the body. Thus, to mitigate these effects, significant research has been done to attaching drugs to nanocarriers that range from gold to protein scaffolds. I will be working with protein based nanocarriers, derived from the tobacco mosaic virus to increase the efficacy of the... Read More

Analysis of the TGFβ induced enhancement of procollagen I secretion

Juliet Hemmati : Molecular and Cell Biology, Economics Summer 2016

Collagen is the most abundant protein in mammals: it is essential for tissue development and homeostasis, and its dysfunction contributes to tumor progression. As a major component of the extracellular matrix (ECM), collagen is secreted by specialized cells such as fibroblasts. In the tumor microenvironment, transforming growth factor-β (TGFβ) released by tumors can... Read More

Vertical Integrated Reactor for Photocatalysis

Dylan Kato : Civil and Environmental Engineering Summer 2016

Building activity accounts for 25% of the world's water consumption and 40% of the world's energy demand. Much of the water comes into buildings at drinking quality and is used for all the water demand throughout the building, including uses that don’t require drinking quality water, such as landscaping and toilet flushing. This leaves huge potential for water... Read More

Cancer Targeting Nanorods via Peptoid Mediated Antibody Bioconjugation

Andrew Kelleghan : Chemical and Biomolecular Engineering Summer 2016

In 2012 alone, 14.1 million cases of cancer were reported worldwide and the disease claimed 8.2 million lives. The magnitude of these figures speaks to the complexity of the causes and mechanisms of cancers and the need to develop new strategies to better combat the disease state. Existing treatments such as chemotherapy and radiation can prove effective but are... Read More

Evaluating the Toxicity of Flame Retardant Compounds to Human Kidney Cells

Charles Li : Molecular and Cell Biology Summer 2016

Flame retardants are a diverse group of chemicals designed to slow down or prevent the spread of fire. Exposure to these compounds, however, is associated with adverse—and often irreversible—developmental, reproductive and carcinogenic consequences. Despite the prevalence of flame retardants in the furniture, electronics, and clothing industries, little is known about... Read More

Arranging Atoms: Relating Crystal Structure to Dielectric and Piezoelectric Response

David Mrdjenovich : Materials Science and Engineering Summer 2016

Throughout human history, advances in materials science have heralded new periods of technological advancement, from the stone to the modern silicon age. By harnessing newfound computational power, it is now possible to design materials on the atomic scale and accurately predict their properties, based solely on the knowledge of their structure and composition. Such... Read More

Determining the Regulatory Genes Involved in Interspecies Interactions

Daniel Polyakov : Molecular and Cell Biology Summer 2016

Due to the overuse of antibiotics, bacterial resistance has become one of the most widespread epidemics facing the world today. This, combined with a significant decrease in the production of antibiotics has created a need for new drugs to combat bacterial infections. Actinomycetes are a class of bacteria known to produce several secondary metabolites important in... Read More

The Elucidation of a Host Race Formation of Oak Mistletoe (Phoradendron leucarpum subsp. tomentosum)

Justin Rigby : Genetics and Plant Biology Summer 2016

Mistletoe is a parasitic organism that inhabits many different tree species in North America. One of the most common mistletoe species is the Oak Mistletoe (Phoradendron villosum) which inhabits a few different oak species in Northern/Central California. They grow in large green clumps and on the trees and produce white berries in the fall and winter seasons. These... Read More

Development of an Apparatus to Measure Relative Reflectivity of Teflon Samples to 175 nm Light in Liquid Xenon

Logan Rudd : Physics Summer 2016

The LUX-ZEPLIN dark matter experiment is currently investigating the use of PTFE (Polytetraflouroethylene) best known as Teflon, for the internal walls of its liquid xenon detector, due to its high reflectivity for 175 nm light. In order to streamline research and development of the PTFE to be used in the detector, a new apparatus is currently being developed at... Read More

Developing a Mechanical Model for Self-Organization in the Mammary Duct

Saam Shahrokhi : Chemical Engineering & Materials Science and Engineering Summer 2016

It is estimated that about 300,000 women will be diagnosed with breast cancer in 2016, making it cancer’s most common form. About twenty percent of these cases are classified as ductal carcinoma in situ (DCIS), meaning that within the milk duct (ductal) of the mammary gland, cancerous epithelial tissue (carcinoma) has formed, and it is still localized to where it... Read More

Structural Basis of Macrolide Sensitivity and its Impacts on Antibiotic Design and Use

Daniel Srole : MCB: Biochemistry & Molecular Biology Summer 2016

With our overuse of antibiotics and the resulting decline in their effectiveness, it has become increasingly important to understand their mechanisms of action.  Many antibiotics act on harmful bacteria by targeting ribosomal processes and disrupting the translation from mRNA to proteins, thereby interrupting gene expression.  The cell’s abilities to function and... Read More

Cycloprodigiosin Enzyme Discovery: Searching for the Gene Implicated in the Biosynthesis of a Novel Marine Natural Product

Parker Stow : Chemical Biology Summer 2016

Cycloprodigiosin is a novel chemical compound produced by a number of marine bacterial species. One such species of cycloprodigiosin producing bacteria, Pseudoalteromonas rubra or P. rubra, is convenient in that it has had its genome fully sequenced. The gene(s) responsible for the synthesis of cycloprodigiosin from its precursor prodigiosin, however, are yet still... Read More

Scleral Micro-RNAs as Potential Therapeutic Targets For Myopia

Ashley Tang : Nutritional Sciences Summer 2016

Myopia, or nearsightedness, is a condition in which the eye is unable to focus distant objects correctly due to a mismatch between the power of the eye and the length of the eyeball. The outermost layer of the eye, the sclera, is responsible for maintaining eye size. Thinning of the sclera is a leading cause of ocular complications in people with myopia, and even low... Read More

Plasma Spray AR Coating of CMB Optics

Steven Tran : Engineering Physics Summer 2016

Studying the Cosmic Microwave Background (CMB) requires highly sensitive optical instrumentation. I will be developing antireflective (AR) coating for lenses to be deployed in Chile to study the CMB. These AR coatings lower reflective loss, help separate CMB signals from other interference, and increase the bandwidth of the signal from the early universe.
I will... Read More