Displaying 1 - 21 of 21

Investigating the Functional Crosstalk Between the Crucial Epigenetic Silencers PRC1 and PRC2

Curtis Beck : Molecular and Cell Biology Summer 2019

In mammals, the Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2) play crucial roles in maintaining gene expression patterns that enforce cell differentiation during embryonic development. Both complexes silence genes by post-translationally modifying the histone tails of nucleosomes, the smallest structural unit of chromatin. PRC1 plays a role in chromatin compaction... Read More

Developing of Reductive Loop Design Principles for Polyketide Synthases

Sami Chang : Bioengineering Summer 2019

The consumption of petroleum-based gasoline, diesel, and jet fuel continues to affect greenhouse gas emissions and air pollution. Alternative fuel sources are needed, and recent breakthroughs in synthetic biology provide a promising solution: the engineering of microorganisms to generate ‘drop-in’ biofuels, which are compatible with existing engines.

Unlike... Read More

Uncovering the Physical Properties of Fingerprint Treads Under Dynamic Wet Conditions

Ethan Chung : Bioengineering Summer 2019

This summer, I will be looking into the natural phenomenon of wet-induced fingertip wrinkling and the possible dynamic benefits which could come with implementing and mimicking its main properties in a mechanical system.
Similar to how tire treads can improve a car’s efficiency and safety on the road during heavy precipitation and how shoe treads help prevent... Read More

Probing Unknown Proteins from a Unique Genetic Island in Vibrio Cholerae

Peter DePaola IV : Chemical Biology Summer 2019

The current treatment for cholera infection is hydration with sanitary water and salts to replenish the nutrients and water lost through diarrhea. The World Health Organization estimates that 120,000 people die each year from cholera infection alone, with the majority of deaths in developing countries which have neither the infrastructure nor resources to treat... Read More

Structure and Properties of the Iron Sulfur Enzyme, the "Hybrid Cluster Protein"

Noah Epstein : Chemical Biology Summer 2019

Iron sulfur enzymes perform some of life’s most challenging chemical transformations, but how these enzymes function is largely unknown. I will be researching the structure, reactivity, and reduction/oxidation properties of a particular iron sulfur enzyme, the hybrid cluster protein (HCP), whose physiological function is unknown despite its presence in all domains of... Read More

Cooling Electrons through Resonant Mode-Mode Coupling

Huws Landsberger : Physics Summer 2019

Low temperature plasma physics is of importance to antimatter research, where sympathetic (collisional) cooling with a matter plasma brings energetic antimatter particles to a temperature at which creation of antiatoms is possible. Resonant cavity cooling, or cooling of a nonneutral plasma by coupling the radiation field with the electromagnetic modes inside a trap... Read More

Extracellular Electron Transport in Listeria monocytogenes

Frank Lee : Microbial Biology Summer 2019

Listeria monocytogenes is a Gram-positive pathogenic bacterium that causes the foodborne illness Listeriosis in humans. The Portnoy lab discovered that L. monocytogenes has the ability to do extracellular electron transfer (EET), which consists of transferring electrons from the inside of the bacteria to extracellular acceptors outside, using compounds called flavins.... Read More

Secure Prediction for Neural Networks

Ryan Lehmkuhl : EECS Summer 2019

Machine learning classification is growing increasingly important for a variety of industries and applications, including medical imaging, spam detection, facial recognition, financial predictions, and more. As understanding of these systems advances, so do attacks which seek to exfiltrate information from exposed models. These models are often trained on confidential... Read More

Understanding Neuroendocrine Mechanisms Underlying the Impact of Stress on Pregnancy

Diana Leslie Cornejo : Molecular and Cell Biology Summer 2019

Chronic stress has been shown to have lasting and damaging effects on an individual’s physical and mental health. One of the avenues of life that stress can impact significantly is female fertility and reproductive success. Prenatal stress leads to lower birth weights of fetuses, decreased success rate of full-term pregnancies, and delayed development. Although studies... Read More

Regulation of Kinetochore Subunit Ndc80 During the Mitotic Cell Cycle in Yeast

Andrew Liao : MCB - GGD Summer 2019

Cell division is a highly regulated process through which organisms generate new cells. From a single fertilized egg, a whole organism is developed after many cell divisions have occurred. Since the majority of these divisions are mitosis, errors in mitosis can cause lethal embryos due to loss of genetic material. Therefore, it is crucial for a mitotic cell to... Read More

Site-Specific Modification of Virus-Like Particles for Cancer Drug Delivery

Zoe Merz : Chemical Biology Summer 2019

Common cancer therapies, such as chemotherapy, have harsh side effects because they damage both healthy and cancerous cells. Therapies that deliver drugs directly to cancer cells eliminate this issue. Protein nanocages, coupled with cancer targeting ligands, are attractive drug delivery vessels due to their biocompatibility and reduced toxicity. One such protein... Read More

Obtaining Paleomagnetic Data to Understand Rotation of the Baird Formation

Leyla Namazie : Geophysics Summer 2019

During their formation, all rocks are exposed to Earth’s magnetic field. The subsequent magnetization of their individual ferromagnetic minerals preserves a record of the field at that moment in time. Described as a rock’s primary ‘natural remanent magnetization’ (NRM), this property allows us to observe changes in the Earth’s geodynamo over the course of history by... Read More

Investigating the strength of remote sensing technologies in analyzing wetland biodiversity

Metta Nicholson : Molecular Environmental Biology Summer 2019

Wetlands are habitats valued for their ecosystem services, nutrient cycling abilities, biodiversity, and buffering capacity, but have been rapidly declining since the eighteenth century. Only recent efforts have attempted to address wetland decline, and such large-scale analyses of wetland composition face complications regarding the difficulty of site access and the... Read More

Identifying Triterpene Derivatives for a New Generation of Non-Hormonal Contraceptives

Natalie Petersen : Molecular Cellular Biology Summer 2019

According to a 2013 National Health Statics Report, 30% of American women discontinue using hormonal methods of birth control within their first year of use due to side effects. Conventional steroid-based contraception comes with a variety of side effects, such as anxiety, depression, and weight gain, and therefore creates a demand for non-hormonal contraceptive with... Read More

Observing Histone Loss in Individual Nucleosomes through Mechanical Unwrapping

Andy Quaen Chen : MCB - BMB Summer 2019

I will investigate how histones dissociate from the nucleosome during the process of unwrapping by using "Fleezers," optical tweezers with the added capability of detecting single molecule fluorescence. In all Eukaryotic cells, DNA is packaged and compacted in the form of chromatin in the nucleus. The nucleosome, consisting of a histone octamer core wrapped by 1.7... Read More

The Interplay of Linkage Disequilibrium Score Regression and Selection

Courtney Rauchman : Data Science Summer 2019

The current method to estimate heritability based on genome-wide association studies (GWAS) summary statistics is to use Linkage Disequilibrium Score Regression (LDSC). Linkage Disequilibrium (LD) describes the association of genetic variants and LDSC makes use of the fact that variants which “tag” many other variants through high LD are more likely to tag a causal... Read More

Engineering Halogenase Enzymes for Selective Chlorination of Therapeutics

Nikko Sambold : Molecular and Cellular Biology Summer 2019

Halogens, a group of atoms with properties not commonly encountered in nature, can introduce unique chemical properties to small molecules that can create important interactions with biomolecules. It is thus reflective that halogens are found in roughly 25% of pharmaceuticals and have been playing a larger role in the development of agrochemicals. Unfortunately, modern... Read More

Evaluating the 3,4,3-LI(1,2-HOPO) Chelator as a Gadolinium Decorporation Agent

Elizabeth Wang : Bioengineering Summer 2019

Gadolinium-based contrast agents (GBCAs), consisting of a chelating agent and gadolinium metal (Gd(III)), have been used to enhance magnetic resonance imaging (MRI) contrast for the last 30 years, with over 300 million procedures to date. Because of the electronic magnetic moment of the gadolinium and nearby water molecules, gadolinium can be imaged accurately when... Read More

Disrupted Synaptic Remodeling Due to a Loss of Interleukin-33 Signaling

Brigita Widiarto : Molecular and Cell Biology Summer 2019

... Read More

Investigating the Regulation of Tau Levels

Kirsten Young : MCB Neurobiology and NS Toxicology Summer 2019

Tau is a microtubule-associated protein that ordinarily regulates cytoskeletal stabilization, but is abnormally hyper-phosphorylated and acetylated in neurodegenerative diseases classed as tauopathies. Although little is known about how tau becomes pathological, previous studies showed that the over-activation of the mTOR pathway could be implicated in tau pathogenesis... Read More

Understanding the Directed Outgrowth of the C. elegans Hermaphrodite-Specific Neurons

Sijia Zhang : Molecular and Cell Biology, Anthropology Summer 2019

Directed cell migration and axon guidance are critical for the assembly and connectivity of nervous systems. How neuronal cells are able to establish precise connectivity is a major challenge in developmental neurobiology. Caenorhabditis elegans is an excellent model to address this question due to the simplicity of its nervous system and a well-characterized cell... Read More