Displaying 1 - 23 of 23

CD36-mediated CoQ uptake is integral to normal BAT function

Jazlyn Chong : Integrative Biology Summer 2017

CoQ is an essential molecule in the electron transport chain (ETC) which acts as an electron carrier to help generate adenosine triphosphate (ATP) in the mitochondria. Therefore, without CoQ or under conditions of severe CoQ deficiency, the redox reactions required for efficient energy production are greatly hampered. The inordinately high levels of mitochondria in... Read More

Investigating the role of HERVH in human embryonic stem cell pluripotency

Jonathan Chu : Molecular and Cellular Biology Summer 2017

The non-coding genome has traditionally been viewed as “junk,” with little to no significance in everyday biological functions. However, recent advances have demonstrated clear functional importance of the non-coding genome in both development and disease. Of particular interest are the retrotransposons (RTs), mobile genetic elements that copy themselves through RNA... Read More

Investigating the Molecular Mechanism of Heterochromatic Gene Silencing

Ryan Chung : Molecular and Cell Biology Summer 2017

The heterochromatin domain is an essential component of the eukaryotic genome, which contains many repetitive non-protein-coding sequences that must be transcriptionally silenced to maintain genomic integrity. Heterochromatic sequences from multiple chromosomes are organized into nuclear domains that concentrate heterochromatic proteins and exclude euchromatic factors... Read More

Horizontal Gene Transfer of a tet(C)-containing casette between Chlamydia suis and Chlamydia trachomatis

Stacey Dojiri : Molecular and Cell Biology (Infectious Disease) Summer 2017

Many strains of Chlamydia suis, a bacteria that infects the intestinal tracts of pigs, are resistant to an antibiotic called tetracycline. My project studies whether the gene conferring tetracycline resistance can be transferred from Chlamydia suis to a different species - for example, Chlamydia trachomatis.  C. trachomatis is the leading cause of bacterial sexually... Read More

Immobilizing Iron Ions Using Porous Supports for Catalysis

Franco Faucher : Chemistry Summer 2017

Metal catalysts are extremely useful, however, there are many practical challenges that impede their use. One of these challenges is that most metal catalysts are prepared from precious metals; meaning that they might not be practically affordable. In order to circumvent the rising costs of metals and achieve recyclability, I will be synthesizing Dendrimer Encapsulated... Read More

Identifying Genes Involved in CRISPR/Cas9 Gene Editing

Sharon Feng : Molecular and Cell Biology, Business Administration Summer 2017

Genome editing is an emerging topic with immediate and significant implications in human health. Despite interest in therapeutic gene editing technologies, such as CRISPR/Cas9, interactions between genome editing reagents and human cells remain poorly understood. Prior work in the Corn Lab identified how human cells integrate single stranded DNA into Cas9 cut sites. My... Read More

Characterizing steptococcus pyogenes infection in hexokinase 2 deficient macrophages.

Christopher Hernandez : Molecular and Environmental Biology Summer 2017

It was recently discovered that hexokinase 2, a cellular metabolic enzyme, can act as a pathogen pattern recognition receptor and activator of the inflammasome within macrophages. Specifically, hexokinase 2 is activated by a saccharide subunit of the peptidoglycan cell wall found in many bacteria. Gram + bacteria have a greater abundance of cell wall subunits available... Read More

Cardiac regenerative potential across mammalian phylogeny

Alison Hoang : Molecular & Cell Biology Summer 2017

The heart, especially in adult mammals, is one of the least regenerative organs as evident in the ongoing battle against cardiovascular diseases. While higher mammals lack the ability to proficiently regenerate myocardial tissue, lower vertebrates, such as zebrafish and newts, experience a robust regenerative response even after major injury. Phylogeny then implies... Read More

Investigating Thermodynamic Properties of Honeycomb Systems FePS3 and RuPS3

Caolan John : Physics Summer 2017

Quantum mechanics shows us that the electronic energy levels of isolated atoms are discrete. Upon the formation of a solid with many atoms, these energy levels merge to become quasi-continuous functions of the electron’s momentum known as energy bands. In CeSb, the structure of these energy bands protects the stability of a semimetal state that would, in the absence of... Read More

High-Throughput Imaging of DNA Holliday Junctions

Harrison Khoo : Bioengineering Summer 2017

DNA Holliday junctions (HJs) are double-stranded structures that promote genetic variation during DNA replication. Errors during separation of the two strands that comprise the HJ may lead to various biological issues contributing to human disease. The Redding Lab seeks to approach this problem by first learning more about the biophysical properties of HJs. We look to... Read More

Ground State Energy Determination Using Tensor Networks

Vladimir Kremenetski : Physics Summer 2017

Quantum computers have the potential to solve several useful classes of problems exponentially faster than their classical counterparts. A group of problems that is of particular interest is the determination of the ground states of strongly correlated quantum systems. Developing a computer capable of running such simulations would have a revolutionary impact on the... Read More

Evolution of multicellularity: Capture of unicellular versus multicellular choanoflagellates by a protozoan predator

William Kumler : Marine Science/Molecular, Environmental Biology Summer 2017

All animals are multicellular, but why? My research this summer hopes to answer a part of this question by studying animals' closest living relative: choanoflagellates. These organisms can be either unicellular or colonial, and it's been theorized that this discrepancy is due to specific predation- where predators prefer either colonial or unicellular choanoflagellates... Read More

Investigating the degradation of a kinetochore protein, Ndc80p, during meiosis

Hanna Liao : Molecular and Cell Biology Summer 2017

Sexual reproduction in almost all known organisms requires a specialized cell division named meiosis. Errors in this cell division are the leading cause of genetic disorders such as Down’s syndrome, miscarriages, and congenital birth defects in humans. To ensure the success of meiosis, chromosomes undergo a dynamic restructuring of their kinetochores, which mediate... Read More

Optimizing the Synthesis of CVD Single Crystal Few-Layer h-BN for Graphene Electronic Devices

Stanley Liu : Physics, Computer Science Summer 2017

With the initial discovery and isolation of graphene in 2004, there have been many studies in other 2D materials. One such material is hexagonal boron nitride (hBN), otherwise known as “white graphene,” due to its structural similarity to graphene but electrically insulating qualities. hBN plays a unique role as a dielectric layer when paired with graphene, vastly... Read More

Probing the Kinetics and Mechanism of Acetalization of Ketones and Aldehydes with Various Diols and Heterogeneous Acid Catalysts

Alan Liu : Chemical Engineering Summer 2017

The use of fossil fuels to produce fuels is leading to an increase in changes of global climate due to the large amount of carbon dioxide released. Fossil reserves are also becoming scarcer, so alternative energy sources such as those from biomass derived alcohols are becoming more important. It is known that some biomass derived alcohols, such as glycerol, can react... Read More

Evaluation of the Localization Ability of a Commercial Off-The-Shelf Drone for Active Cooperative Localization

Eugene Lo : Electrical Engineering and Computer Science Summer 2017

A key component of successfully automating robots is localization: maintaining realtime knowledge of the robots' positions and orientations in some local environment. Tools such as GPS can achieve reasonably accurate localization via absolute position estimates (e.g. a longitude, latitude measurement), but these absolute sensors often do not work well in indoor... Read More

The role of inflammatory signaling and blood brain barrier degradation in cognitive decline

Ada Locke : Molecular and Cell Biology, Neurobiology Summer 2017

As we age, the protective barrier that separates circulating blood from neural tissue loses efficacy. Breakdown in this blood-brain barrier leads to excitatory synaptic remodeling, epileptoform activity, and, we hypothesize, cognitive dysfunction as seen in Alzheimer’s disease and dementia pathologies. The protein albumin in the blood is normally separated from brain... Read More

Synthesis of a Homochiral Metal–Organic Framework

Leo Porter-Zasada : Chemistry Summer 2017

In this project, I will attempt to create a less expensive and more effective method to
synthesize and separate chiral compounds in large quantities. Because a large percentage of biological molecules are chiral (i.e. they have non-superimposable mirror images), many bioactive and pharmaceutical compounds are also chiral, and separations and synthesis of these... Read More

Manipulating Hepatitis B Virus-like Particles through Mutations

Stephanie Robinson : Chemistry Summer 2017

Virus-like particles (VLPs) are non-infectious viral capsids that can be engineered, and serve as a drug delivery scaffolds.The MS2 bacteriophage is a VLP that has already proven to be a robust and mutable VLP by the Francis group. I am utilizing the same techniques to another VLP, the Hepatitis B virus (HBV), to identify if this is a universal quality that can be... Read More

Millimeter scale CMOS imager

Amanda Tomlinson : Electrical Engineering and Computer Science (EECS) Summer 2017

Technology has improved many aspects of our lives, but some of the largest changes have come in medicine. One large area of improvement is developing sensors that continuously monitor human health. These sensors need to be small enough to be non-invasive, and be low power so they can be used for a long time without being replaced. The aim of my research is to design... Read More

Phylogenetic and Biogeographic Analysis of Craneflies (Diptera: Tipulomorpha)

Ivonne Verduzco : Molecular and Cell Biology: Developmental Genetics Summer 2017

Members of the superfamily Tipuloidea, commonly called craneflies, are the largest group of Diptera, or flies. There are currently 18,000 species known. While this group is an important player in most ecosystems, serving as general decomposers, predators, or crop pests, little is known about the relationships between cranefly families or genera. My research is aimed at... Read More

Development of Pseudomonas putida as a genome mining host for antimicrobial discovery

Andrew Wong : Molecular and Cell Biology Summer 2017

With the increasing threat of antimicrobial resistance, there is great demand for the development of new antibiotics. Natural products, which are biologically produced substances, are used as the primary reference for the development of antibiotics and drug development.  Recent developments in metagenomics, the field of recovering genetic material from environmental... Read More

Using Light to Control Embryonic Development

Jordan Xiao : Physics Summer 2017

At the level of transcription, gene expression is controlled by activator and repressor proteins (transcription factors) which bind to DNA in concentration-dependent manners. Current models in biophysics depict transcriptional regulation as an input-output function where the output rate of mRNA synthesis depends on the concentrations of input transcription factors. Our... Read More